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Learn more about exciting markers and disease groups, including plasma cell dyscrasia, chronic alcohol abuse, renal diseases, cardiovascular risk, and more.

N Latex FLC serum free light-chain assays in patients with renal impairment.
Jacobs JFM, Hoedemakers RMJ, Teunissen E, te Velthuis H.
Clin Chem Lab Med 2014; e-pub Jan 9
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Association between free light chain levels, and disease progression and mortality in chronic kidney disease.
Desjardins L, Liabeuf S, Lenglet A, et al.
Toxins 2013; 5: 2058-73.
Open access 

Evaluation of the N Latex free light chain assay in the diagnosis and monitoring of AL amyloidosis.
Molle P, Tate J, Pretorius CJ.
Clin Chem Lab Med. 2013; e-pub Aug 8
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Determination of kFLC and k index in cerebrospinal fluid: a valid alternative to assess intrathecal immunoglobulin synthesis.
Duranti F, Pieri M, Centonze D, et al.
J Neuroimmunol 2013; 263: 116-20
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A multicenter study comparing two methods for serum free light chains.
Lock RJ, Saleem R, Roberts EG, et al.
Ann Clin Biochem 2013; 50: 255-61
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N Latex FLC - new monoclonal high-performance assays for the determination of free light chain kappa and lambda.
te Velthuis H, Knop I, Stam P, et al., Clin Chem Lab Med. 2011;49(8):1323-32
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Evaluation of the N Latex FLC free light chain assay on the Siemens BN analyzer: precision, agreement, linearity and variation between reagent lots.
Pretorius CJ, Klingberg S, Tate J, et al., Ann Clin Biochem. 2012;49(Pt 5):450-5
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Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 3.
Dimopoulos M, Kyle R, Fermand JP, et al., Blood 2011;117(18):4701-5
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Guidelines on the diagnosis and management of multiple myeloma.
British Committee for Standards in Haematology (BCSH) in conjunction with the UK Myeloma Forum (UKMF), 2010
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Serum free light chain analysis.
Davids MS, Murali MR, Kuter DJ., Am J Hematol 2010;85(10):787-90
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Clinical comparison of new monoclonal antibody-based nephelometric assays for free light chain kappa and lambda to polyclonal antibody-based assays and immunofixation electrophoresis.
Hoedemakers RM, Pruijt
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Development and multicenter evaluation of the N latex CDT direct immunonephelometric assay for serum carbohydrate-deficient transferrin.
Delanghe JR, Helander A, Wielders JP, et al., Clin Chem. 2007;53(6):1115-21
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The diagnostic power of direct carbohydrate-deficient transferrin immunoassay in alcoholics. Absolute or relative values?
Chrostek L, Cylwik B, Gruszewska E, Tobolczyk J., Alcohol. 2012 Feb;46(1):69-73
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A novel C2 transferrin variant interfering with the analysis of carbohydrate-deficient transferrin.
de Wolf HK, Huijben K, van Wijnen M, de Metz M, Wielders JP., Clin Chim Acta. 2011;412(17-18):1683-5
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Alteration of biological markers in alcohol-dependent individuals without liver disease during the detoxification therapy.
Chatzipanagiotou S, Kalykaki M, Tzavellas E, et al., In Vivo. 2010;24(3):325-8
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Alcohol biomarkers as tools to guide and support decisions about intoxicated driver risk.
Bean P, Roska C, Harasymiw J, Pearson J, Kay B, Louks H., Traffic Inj Prev. 2009 Dec;10(6):519-27
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β-Trace protein: a marker of GFR and other biological pathways.
White CA, Ghazan-Shahi S, Adams MA., Am J Kidney Dis. 2015;65(1):131-46.
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Reference ranges for serum β-trace protein in neonates and children younger than 1 year of age.
Zwiers AJ, Cransberg K, de Rijke YB, Willemsen SP, de Mol AC, Tibboel D, de Wildt SN., Clin Chem Lab Med. 2014;52(12):1815-21.
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Beta-trace protein as a marker of GFR--history, indications, and future research.
Filler G, Kusserow C, Lopes L, Kobrzyński M., Clin Biochem 2014;47(13-14):1188-94.
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Estimating kidney function in a multiethnic Asian population with multiple filtration markers.
Teo BW, Xu H, Koh YY, Li J, Sinha AK, Shuter B, Sethi S, Lee EJ., Am J Kidney Dis. 2012;60:500-2.
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Development of a beta-trace protein based formula for estimation of glomerular filtration rate.
Benlamri A, Nadarajah R, Yasin A, Lepage N, Sharma AP, Filler G., Pediatr Nephrol. 2010;25(3):485-90.
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Beta-trace protein-based equations for calculation of GFR in renal transplant recipients.
Pöge U, Gerhardt T, Stoffel-Wagner B, Palmedo H, Klehr HU, Sauerbruch T, Woitas RP., Am J Transplant. 2008;8:608-15.
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Urinary beta-trace protein as a new renal tubular marker.
Vynckier LL, Floré KM, Delanghe SE, Delanghe JR., Clin Chem. 2009;55:1241-3.
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Evaluation of renal damage by urinary beta-trace protein in patients with chronic kidney disease.
Dajak M1, Ignjatović S, Stojimirović B, Gajić S, Majkić-Singh N., Clin Lab. 2011;57(1-2):29-36.
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Novel filtration markers as predictors of all-cause and cardiovascular mortality in US adults.
Foster MC1, Inker LA, Levey AS, Selvin E, Eckfeldt J, Juraschek SP, Coresh J; CKD Biomarkers Consortium, Am J Kidney Dis. 2013;62:42-51.
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Novel markers of kidney function as predictors of ESRD, cardiovascular disease, and mortality in the general population.
Astor BC, Shafi T, Hoogeveen RC, Matsushita K, Ballantyne CM, Inker LA, Coresh J., Am J Kidney Dis. 2012;59:653-62.
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Comparison of measured GFR, serum creatinine, cystatin C, and beta-trace protein to predict ESRD in African Americans with hypertensive CKD.
Bhavsar NA1, Appel LJ, Kusek JW, Contreras G, Bakris G, Coresh J, Astor BC; AASK Study Group., Am J Kidney Dis. 2011;58:886-93.
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Serum β-trace protein and risk of mortality in incident hemodialysis patients.
Shafi T, Parekh RS, Jaar BG, Plantinga LC, Oberai PC, Eckfeldt JH, Levey AS, Powe NR, Coresh J., Clin J Am Soc Nephrol. 2012;7:1435-45.
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Serum levels of beta-trace protein and its association to diuresis in haemodialysis patients.
Gerhardt T, Pöge U, Stoffel-Wagner B, Klein B, Klehr HU, Sauerbruch T, Woitas RP., Nephrol Dial Transplant. 2008;23:309-14.
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Different elimination patterns of beta-trace protein, beta2-microglobulin and cystatin C in haemodialysis, haemodiafiltration and haemofiltration.
Lindström V, Grubb A, Alquist Hegbrant M, Christensson A., Scand J Clin Lab Invest. 2008;68:685-91.
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The importance of residual renal function for patients on dialysis.
Bargman JM, Golper TA., Nephrol Dial Transplant. 2005;20:671-3.
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Early start of dialysis: a critical review.
Rosansky S, Glassock RJ, Clark WF., Clin J Am Soc Nephrol. 2011;6:1222-8.
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Clinical benefit of preserving residual renal function in dialysis patients: an update for clinicians.
Brener ZZ, Kotanko P, Thijssen S, Winchester JF, Bergman M., Am J Med Sci. 2010;339:453-6.
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EBPG guideline on dialysis strategies.
Tattersall J, Martin-Malo A, Pedrini L, Basci A, Canaud B, Fouque D, Haage P, Konner K, Kooman J, Pizzarelli F, Tordoir J, Vennegoor M, Wanner C, ter Wee P, Vanholder R., Nephrol Dial Transplant. 2007;22 Suppl 2:ii5-21.
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National Kidney Foundation / KDOQI 2006 Updates Clinical Practice Guidelines and Recommendations.
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The clinical utility of high-sensitivity C-reactive protein in cardiovascular disease and the potential implication of JUPITER on current practice guidelines.
Mora S, Musunuru K, Blumenthal RS., Clin Chem. 2009;55(2):219-28
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National Academy of Clinical Biochemistry Laboratory Medicine Practice guidelines: emerging biomarkers for primary prevention of cardiovascular disease.
NACB LMPG Committee Members, Myers GL, Christenson RH, et al., Clin Chem. 2009;55(2):378-84
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C-reactive protein and reclassification of cardiovascular risk in the Framingham Heart Study.
Wilson PW, Pencina M, Jacques P, et al., Circ Cardiovasc Qual Outcomes. 2008;1(2):92-7
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C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus.
Ridker PM., J Am Coll Cardiol. 2007;49(21):2129-38
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Clinical application of C-reactive protein across the spectrum of acute coronary syndromes.
Scirica BM, Morrow DA, Cannon CP, et al., Clin Chem. 2007t;53(10):1800-7
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Rapid, accurate and non-invasive detection of cerebrospinal fluid leakage using combined determination of beta-trace protein in secretion and serum.
Risch L, Lisec I, Jutzi M, Podvinec M, Landolt H, Huber AR., Clin Chim Acta. 2005;351:169-76.
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Beta-trace protein as sensitive marker for CSF rhinorhea and CSF otorhea.
Reiber H, Walther K, Althaus H., Acta Neurol Scand. 2003;108:359-62
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Beta-Trace protein as a marker for cerebrospinal fluid rhinorrhea.
Arrer E, Meco C, Oberascher G, Piotrowski W, Albegger K, Patsch W., Clin Chem. 2002;48:939-41
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Beta-trace protein test: new guidelines for the reliable diagnosis of cerebrospinal fluid fistula.
Meco C, Oberascher G, Arrer E, Moser G, Albegger K., Otolaryngol Head Neck Surg. 2003;129:508-17.
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Efficacy of cerebrospinal fluid fistula repair: sensitive quality control using the beta-trace protein test.
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Predictive values of beta-trace protein (prostaglandin D synthase) by use of laser-nephelometry assay for the identification of cerebrospinal fluid.
Bachmann G, Petereit H, Djenabi U, Michel O., Neurosurgery. 2002;50:571-7.
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A new nephelometric assay for beta-trace protein (prostaglandin D synthase) as an indicator of liquorrhoea.
Petereit HF, Bachmann G, Nekic M, Althaus H, Pukrop R., J Neurol Neurosurg Psychiatry. 2001;71:347-51.
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Cerebrospinal fluid leakage--reliable diagnostic methods.
Mantur M, Łukaszewicz-Zając M, Mroczko B, et al., Clin Chim Acta. 2011;412:837-40.
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EFNS guidelines on disease-specific CSF investigations.
Deisenhammer F., Egg R., Giovannoni G., Hemmer B., Petzold A., Sellebjerg F., Teunissen C., Tumani H; EFSN.,
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Diagnostic values of beta-2 transferrin and beta-trace protein as markers for cerebrospinal fluid fistula.
Bachmann-Harildstad G., Rhinology. 2008; 46:82-5.
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Reference and interpretive ranges for α(1)-antitrypsin quantitation by phenotype in adult and pediatric populations.
Donato LJ, Jenkins SM, Smith C, et al., Am J Clin Pathol. 2012;138(3):398-405
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Diagnosis of alpha-1-antitrypsin deficiency: An algorithm of quantification, genotyping, and phenotyping.
Snyder MR, Katzmann JA, Butz ML et al., Clin Chem. 2006;52(12):2236-42
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Iron deficiency and erythropoiesis: new diagnostic approaches.
Brugnara C., Clin Chem. 2003;49(10):1573-8
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Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency.
Thomas C, Thomas L., Clin Chem. 2002;48(7):1066-76
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Determination of iron metabolism-related reference values in a healthy adult population.
Van den Bosch G, Van den Bossche J, Wagner C, et al., Clin Chem. 2001;47(8):1465-7
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Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays.
Lepage N, Huang SH, Nieuwenhuys E, Filler G., Clin Biochem. 2010;43(7-8):694-6
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