Siemens offers new standardized Vitamin D Total assay

Healthcare News | 2014-08-11

Vitamin D Deficiency

Siemens is pleased to announce the availability of our standardized ADVIA Centaur® Vitamin D Total assay to align with the ID-LC/MS/MS 25(OH)vitamin D Reference Measurement Procedure (RMP)1,2. The RMP is a reference procedure of the National Institutes of Health's Office of Dietary Supplements' Vitamin D Standardization Program (VDSP), an initiative to standardize 25(OH)vitamin D measurement across methods and manufacturers.

The ADVIA Centaur Vitamin D assay is also a certified procedure of the Centers for Disease Control (CDC) Vitamin D Standardization-Certification Program (VDSCP)3, a program to improve diagnosis, treatment, and prevention of diseases by standardizing clinical laboratory measurements.

The revised ADVIA Centaur Vitamin D Total assay will enhance accuracy and reliability, providing clinicians and patients with a clear understanding of their results.

ADVIA Centaur Vitamin D Total Assay

Vitamin D Deficiency

Globally, over 1 billion people are vitamin D deficient1, and deficiency rates have increased as people have limited their sun exposure due to the risk of skin cancer. Vitamin D deficiency has long been associated with rickets in children and osteomalacia in adults, and long-term insufficiency of calcium and vitamin D leads to osteoporosis. However, in recent years, vitamin D has become an indicator of general health status, and there have been multiple publications linking vitamin D deficiency to several disease states, such as cancer, cardiovascular, diabetes, and autoimmune diseases2. This, in turn, has led to more commercially available automated vitamin D assays. However, since there has not been a universal vitamin D standard, different vitamin D assays and methods produced varying results, raising the need for standardization among manufacturers and assays. Vitamin D standardization is necessary to create the anchor vitamin D values need.

ADVIA Centaur Vitamin D Total Assay

Laboratories can now meet the demands of increased vitamin D testing and have confidence in consistent and clinically accurate patient results by consolidating their testing on a fully automated, high-throughput immunoassay system. Features of the ADVIA Centaur Vitamin D Total assay include:

Key Benefits

  • · Total measurement of 25(OH)vitamin D2 and D3
  • · Fast turnaround time – XP: 18 minutes
  • · Traceability to ID-LC/MS/MS 25(OH)vitamin D RMP
  • · Broad dynamic assay range 4.2 – 150 ng/mL
  • · Now available with pediatric (1-21 years) observed values

Contact Center

International (English): +49 69 797 6602
You can call us Monday through Friday
8 am to 5 pm CET

1 Holick MF "Vitamin D deficiency". N.Engl. J. Med. (2007) 357 (3): 266-81.

2 Dietary Supplemental Fact Sheet: Vitamin D. Office of Dietary Supplements. National Institutes of Health. Updated 11/13/2009. Accessed 08/17/2010

3 CDC website (

Product availability may vary by country.

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