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Pictorial Essay ‘White dots’ on Cranial MRI: MS and Differential Diagnosis

Author: Iris N. Kaschka, et al.
Dept. of Neuroradiology, University Hospital Erlangen, Germany

MS is the most common primary demyelinating disease of the CNS. However, differentiation from other demyelinating disorders might be challenging since clinical findings can be subtle and imaging is not always specific. This pictorial essay is intended as an overview of the spectrum of demyelinating disorders and their typical and atypical imaging findings.

The T1-weighted PSIR shows great potential in revealing MS lesions in the cervical spinal cord. While using this technique it is important to use the phase sensitive reconstruction to preserve the contrast between MS lesions and normal appearing tissue. Due to the nature of the reconstruction, and because T1 values of lesions can vary from patient to patient, for reliable depiction of lesions, the phase sensitive reconstruction is recommended. This is as, unlike the magnitude reconstruction, the phase sensitive reconstruction provides a contrast between different tissues that is largely independent of the chosen inversion time.

Date: 2014-09-26


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The information presented is for illustration only and is not intended to be relied upon by the reader for instruction as to the practice of medicine. Any health care practitioner reading this information is reminded that they must use their own learning, training and expertise in dealing with their individual patients. This material does not substitute for that duty and is not intended by Siemens Healthcare to be used for any purpose in that regard.

The drugs and doses mentioned herein are consistent with the approval labelling for uses and/or indications of the drug. The treating physician bears the sole responsibility for the diagnosis and treatment of patients, including drugs and doses prescribed in connection with such use. The Operating Instructions must always be strictly followed when operating the system. The source for the technical data is the corresponding data sheets. Results may vary.

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